Three more trials are going on in China; two coordinated by Tinjian Universiy and a third one in Wuhan’s Union Hospital. We only have a preliminary report of the first two cases. Another trial is waiting for approval in Italy and two more trials are being prepared in Portugal and Brazil, all last three with WFOT’s help. We hope that last trials are approved and we soon get data enough to help our patients. WFOT will not publish preliminary protocols or data without permission from the trial’s coordinator unless it is required by health authorities. Meanwhile, we must follow STRICTLY the advises from these authorities.
UPDATE – 27/03/2020
Other trials have been accepted in hospitals of Romania and Turkey and are pending their ethic committees’ final approval.
UPDATE – 06/04/2020
The University Hospital Santa Maria della Misericordia in Udine – Italy has done a pilot study under the approval of the hospital’s ethical committee. They obtained very positive results in 35 of the 36 patients treated, reducing the intubation rate from 15% to 3%. They have applied for approval from Spallanzani Institute in Rome to start a randomized clinical trial.
UPDATE – 10/04/2020
The University Hospital Santa Maria della Misericordia in Udine – Italy has got approval of its ethical committee to start a randomized clinical trial. Spallanzani Institute in Rome and AIFA (Italian Drug Agency) have declared themselves as not competent to approve the trial as ozone is not a drug. Several hospitals are sending applications to this hospital in order to join its clinical trial.
UPDATE – 01/06/2020
Another hospital in Italy has got approval to start using ozone for COVID-19 by its ethical committee. The Policlinic University Hospital of Bari is treating its COVID-19 patients with systemic indirect endovenous ozone therapy. This will benefit many patients and enforce the recognition of ozone therapy amongst the medical community.
UPDATE – 04/07/2020
The reduced incidence in Italy of COVID-19 is braking the development of the two RCT started in April. Meanwhile, today has been approved in Brazil a multicenter RCT to evaluate the safety and efficacy of ozone in COVD-19. The experience of compassionate use in Perú has reached the milestone of 300 patients.
UPDATE – 06/09/2020
Several publications to justify the use of ozone in COVD-19 have been published in peer-reviewed journal and the first papers on clinical results (case reports with SIEVOT and Rectal Insufflation and non-randomized clinical trials from Spain) are showing the scientific community that ozone therapy is a REAL option in this pandemic.