2019’s Nobel Prize work: a surprising adaptive machinery activated by low oxygen throughout genes modulation.
They identified the molecular mechanism that regulates the activity of genes in response to varying levels of oxygen.
A similar machinery that adapt cells inducing genes activation in response to oxidative stress and Ozone show parallel cellular mechanism.
According to the awarded’s work, when oxygen levels are normal, cells contain very little HIF-1α, a transcription factor that joins onto DNA to activate the synthesis of proteins that regulate the oxygen levels in the body. On the contrary, when oxygen levels are low, the amount of HIF-1α increases so that it can bind to and thus regulate the EPO gene as well as other genes with HIF-binding DNA segments (Figure 1).
Several research groups showed that HIF-1α, which is normally rapidly degraded, is protected from degradation in hypoxia. At normal oxygen levels, a cellular machine called the proteasome, recognized by the 2004 Nobel Prize in Chemistry to Aaron Ciechanover, Avram Hershko and Irwin Rose, degrades HIF-1α. Under such conditions a small peptide, ubiquitin, is added to the HIF-1α protein. Ubiquitin functions as a tag for proteins destined for degradation in the proteasome.
In the last years it is emerging the importance of another intracellular and ubiquitous protein that, differently from H1F, regulates the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation, the Nrf2 machinery (Figure 2). In normal condition and when the oxidative status of the cell is normal the Nrf2 is maintained at low level and, as occurs for HIF-1 α, it is marked with ubiquitin for
proteasome degradation. On the other hand, in case of mild oxidative stress, like that induced by adequate Ozone doses, the levels of Nrf2 increase and following the binding DNA segments it promotes the synthesis of proteins that induce a regulation of the redox status and not only: another surprising adaptive condition in order to maintain our cells health and protected either from hypoxia or from oxidative stress.
We can conclude that the importance of oxygen metabolism is fundamental for life on earth. For the above reason we are not surprised that our cells, during evolution, have equipped themselves with sophisticated machineries in the aim to maintain constant the vital functions even in extreme situations.
The discoveries of these metabolic pathways, such as the one that was worth the Nobel Prize to the 3 colleagues Kaelin, Ratcliffe and Semenza, are becoming clearer.
Cellular defense mechanisms linked to oxygen and oxidative stress are crucial for the live on the Earth.
The perfect machineries that defend the cell in extreme conditions.
The healing power of the human body, a perfect machine!!
In the past General Assembly (April 25th) 2 more society members were accepted:
- Austrian association.
- Moldavian association.
Other associations have recently applied and will be presented for acceptance in the next General Assembly yo be hold in Chile during the next FILAOT meeting.
And also several individual members, some of them from countries without a formal association.
The next WFOT General Assembly will take place on 25th of May in Bucharest (Romania) during the XVIII edition of the SSROOT master classes organized by our President Dr. Stefan Tiron. In the next days, the members entitled to vote will receive an email with the agenda.
Following a wide discussion at the last meeting of Guangzhou, it is in progress a strong work on a new official document that could support all the people associated to us and more. After our first theoretical document (“WFOT’s review on evidence based ozone therapy”) 3 years ago, many of you have asked us to develop clinical guidelines.
We apologize for the delay in preparing this document, that could be intended for a strong support to the daily practice of ozone therapy, trying not to impose methods or forbid others, but to justify scientifically our therapeutic decisions.
It is our aim produce a document which could be used as an international reference advise devoted to the Best Practice of ozone therapy, following the directives of the Scientific Advisory Board and hearing also the most recognized colleagues practicing ozone since its first uses in medicine.
We confirm, then, that we are hardly working on the document discussed in Guangzhou and, very soon, all the ozone therapists could have finally a support to their work. Any other news that could appear on the WEB regarding the possible support of WFOT and its members to Madrid Declaration or other documents not developed by us are not true.
All the re-founding members of WFOT, including our President Dr Tiron and our friend and colleague Dr. Nabil Mawsouf, decided to follow this new road – WFOT – to be faithful to our principles of reinforcing the image of ozone therapy worldwide and creating a unique Home of a unique Family by the use of science.
On yesterday’s General Assembly, Dr. Tiron from Romania was elected new WFOT President for the years 2018-2020. The next WFOT Meeting will take place in Bucarest on October 2020 – final dates to be confirmed.
Dr. Stefan Tiron wants to expand the WFOT in Society and Corporate members and to enhance all the action lines of WFOT, specially the Education program.
The next WFOT General Assembly will take place during the VI WFOT Meeting in Guangzhou – China on 9th of November. We will elect the new officers for the Executive Board for the 2018 to 2020 period, including the President. The only candidate is Dr. Stefan Tiron from Romania, who will organize the VII WFOT Meeting in Bucarest if he is elected. In the next days, the members entitled to vote will receive an email with the agenda.
The WFOT has become bigger after the last General Assembly celebrated on 8th of July.
We welcome the new members:
- American Academy of Ozone Therapy
- Mongolian Ozone and Alternative Therapies Association
- Polish Ozone Association
and for the first time, a Corporate Member:
- Zibo Qianyan Medical Instrument Co., Ltd
Currently we represent 31 countries throughout 23 National Associations, 9 National Sections and 2 Individual Members. We can proudly say that WFOT is the first Society, in terms of number of members worldwide. WFOT has always anchored best values of Good Clinical Practice in the field of Ozone Therapy and its Science.
Due to multiple requests, we have postponed the deadline until 31st of August.
Please do not wait till last day. Send them as soon as possible, please!
UPDATE: In order to prepare the congress agenda, please send title and authors before 1st of July!!!
The morning of 18 April, the Jiangao region of Nanfang hospital, with 51 beds, equipped with DSA, CT, ultrasound, DR and medical ozone generator, ozone fumigation box, ozone bath care equipment, ozone ozone water and oil production equipment can be carried out a variety of equipment, ozone treatment technologies, including ozone autohemotherapy, ozone treatment of cervical and lumbar disc herniation, ozone treatment of various sinus and fistula, ozone treatment of skin disease, ozone, ozone cosmetic enema in the treatment of chronic enteritis, ozone treatment of tubal blockage, and tumor intervention pain.